Name: Blackened Chicken Alfredo Lasagna Roll-Ups Recipe
Prep time: 30 min
Cook time: 35 min
Total time: 1 h 5 min
Cuisine: American
Ingredients: 3 chicken breasts (thighs, cutlets or tenders work too); 4 tablespoons olive oil; 2 tablespoons cajun seasoning (recipe below); 2 tablespoons smoked paprika (regular paprika works too); 1 tablespoon cayenne pepper; 1 tablespoon onion powder; 2 teaspoons brown sugar; 2 teaspoons garlic powder; 1 teaspoon ground black pepper; 1 teaspoon salt; 1/2 teaspoon dried thyme; 1/2 teaspoon dried oregano; 12 lasagna noodle sheets; 1 15 oz ricotta cheese; 1/2 block cream cheese, softened; 12 oz frozen chopped spinach (drained well); Prepared chicken, diced; 1 8 oz block mozzarella (shredded, divided); 1 8 oz block Colby Jack cheese (shredded, divided); 2-3 teaspoons cajun seasoning; 6 tablespoons butter; 6-8 large cloves garlic, minced; 2 cups heavy whipping cream; 1-2 teaspoons cajun seasoning; 1 cup grated parmesan cheese; Salt and pepper to taste; Garlic bread or Texas toast for serving

There’s something irresistible about that smoky, spicy kick paired with creamy comfort, and that’s exactly why this Blackened Chicken Alfredo Lasagna Roll-Ups Recipe has become a go-to in my kitchen. Each bite delivers rich, cheesy goodness wrapped around perfectly seasoned chicken, with a garlicky Alfredo hug that feels like a warm embrace.

A white baking dish filled with a baked cheesy casserole showing three layers: a creamy white sauce with small green herb pieces, a middle layer of pasta covered with gooey melted cheese, and a golden-browned cheese crust sprinkled with chopped green herbs on top; a woman's hand is lifting a large, stringy, melted cheese section from the dish, stretching the cheese in long strands. The dish sits on a white marbled surface. photo taken with an iphone --ar 2:3 --v 7

Jump to:

Why You'll Love This Recipe
Ingredients & Why They Work
Make It Your Way
Step-by-Step: How I Make Blackened Chicken Alfredo Lasagna Roll-Ups Recipe
Top Tip
How to Serve Blackened Chicken Alfredo Lasagna Roll-Ups Recipe
Make Ahead and Storage
Frequently Asked Questions:
Final Thoughts
Blackened Chicken Alfredo Lasagna Roll-Ups Recipe

Why You'll Love This Recipe

I still remember the first time I made these roll-ups—they were a real crowd-pleaser. The combination of textures and flavors keeps everyone coming back for seconds, and it’s easier to pull together than you might think.

Bold Flavor Fusion: The blackened chicken brings a smoky, spicy edge that pairs perfectly with creamy Alfredo sauce.
Layered Creaminess: Ricotta, cream cheese, and mozzarella team up for a luscious filling that’s both cheesy and velvety.
Vegetable Boost: Sneaking in spinach adds freshness and nutrients without overwhelming the dish.
Easy Entertaining: Prepping these roll-ups ahead and popping them in the oven means less stress on game day or family dinners.

The image shows a close-up of a creamy baked dish being lifted from a white ceramic baking dish with a fork. The dish has three main layers: a browned, bubbly, golden cheese crust on top with small green herb flecks, a thick, creamy, off-white sauce layer with visible bits of herbs and spices in the middle, and a soft, melted layer of white cheese underneath. The baking dish has elegant, curved handles and sits on a white marbled surface. Photo taken with an iphone --ar 2:3 --v 7

Ingredients & Why They Work

This recipe balances rich dairy, tender chicken, and aromatic spices beautifully. Choosing fresh, quality ingredients makes all the difference, and I always recommend picking good Parmesan and fresh garlic to elevate the sauce.

Flat lay of twelve uncooked lasagna noodle sheets neatly stacked, three plump raw chicken breasts with smooth skin, a small white bowl of golden olive oil, a small white bowl filled with deep red smoked paprika powder, a small white bowl of bright orange cayenne pepper powder, a small white bowl containing light beige onion powder, a small white bowl of brown sugar crystals, a small white bowl of pale garlic powder, a small white bowl of ground black pepper, a small white bowl of fine white salt, a small white bowl of dried green thyme leaves, a small white bowl of dried oregano flakes, six large whole garlic cloves with papery skins, a pale yellow block of butter, a creamy half-block of soft cream cheese, a mound of white ricotta cheese, a small mound of deep green well-drained chopped spinach, an unshredded block of white mozzarella cheese, an unshredded block of marbled colby jack cheese, a small white bowl of grated parmesan cheese, two whole brown eggs with clean shells for natural contrast — all ingredients arranged with perfect symmetry on a clean white marble surface, soft natural light, photo taken with an iPhone, professional food photography style, fresh ingredients, white ceramic bowls, no bottles, no duplicates, no utensils, no packaging --ar 2:3 --v 7 --p m7354615311229779997

Lasagna noodle sheets: Regular noodles hold their shape well and roll easily; no- boil types save time but watch cooking times.
Chicken breasts (or thighs): I prefer breasts for lean protein, but thighs bring extra juiciness and flavor.
Olive oil: For searing the chicken and adding richness without overpowering other flavors.
Cajun seasoning: This homemade blend packs that signature smoky heat essential for blackened chicken.
Butter: Forms the base of the Alfredo sauce for that silky texture.
Garlic cloves: Fresh minced garlic gives the sauce its vibrant aroma and bold flavor.
Heavy whipping cream: The creaminess cornerstone for the luxurious Alfredo sauce.
Parmesan cheese: Adds nutty, salty depth—always opt for freshly grated for best taste.
Sour cream and ricotta cheese: Ricotta brings creaminess and tenderness to the filling; softened cream cheese adds extra richness.
Frozen chopped spinach: Drained well so it doesn't make the filling watery, plus it adds a lovely pop of green and nutrition.
Mozzarella and Colby jack cheese: Shredded and mixed to create a melty, gooey top crust and filling layer.
Seasonings (paprika, cayenne, onion powder, brown sugar, garlic powder, black pepper, salt, thyme, oregano): These create a complex, smoky, and slightly sweet blackening seasoning that truly makes the chicken pop.

📝

Note: You'll find the complete list of ingredients, along with their exact measurements, in the printable recipe card at the bottom of this post.

Make It Your Way

I love playing around with this roll-ups recipe. Sometimes I'll swap out spinach for kale or roasted red peppers for a little extra color and flavor punch. You should feel free to make it your own—after all, that’s what makes cooking fun!

Variation: Once, I used smoked gouda instead of Colby jack for a deeper smoky profile and it was amazing. Give swapping cheeses a try to find your favorite blend.
Make it vegetarian: Skip the chicken and load up on mushrooms and spinach for a meatless version that’s just as creamy and satisfying.
Add heat: If you like it spicy, sprinkle a few red pepper flakes on top before baking or toss finely diced jalapeños into the filling.

Step-by-Step: How I Make Blackened Chicken Alfredo Lasagna Roll-Ups Recipe

Step 1: Prepare your spices and blacken the chicken

I mix smoked paprika, cayenne, onion powder, brown sugar, garlic powder, black pepper, salt, thyme, and oregano to make the blackening seasoning. Then I rub it generously on the chicken breasts. Heating olive oil in a pan, I sear the chicken over medium-high heat until it’s beautifully charred on the outside and cooked through inside—about 5-6 minutes per side. This step is key for infusing that signature smoky flavor.

Step 2: Cook the lasagna noodles and prep the filling

While the chicken rests, I boil the lasagna noodles according to package instructions until just tender—remember, they’ll cook more in the oven, so no overcooking! Next, I mix together ricotta, softened cream cheese, drained spinach, diced blackened chicken, a pinch of cajun seasoning, and shredded mozzarella and Colby jack cheeses for a flavorful filling.

Step 3: Whip up the garlicky Alfredo sauce

In a saucepan, I melt butter over medium heat, add generous minced garlic, and cook just until fragrant. Then I pour in heavy cream and stir in Parmesan cheese, seasoning with a little salt, pepper, and a touch of Cajun seasoning for continuity of flavor. Stir it gently until it thickens to a creamy, dreamy sauce.

Step 4: Assemble the roll-ups and bake

Lay the noodles flat and spread an even layer of the filling on each. Roll ‘em up tightly and place them seam-side down in a greased 9x13 dish. Pour Alfredo sauce evenly over the top, then cover with the remaining shredded cheeses. I bake everything at 375°F for about 30-35 minutes until bubbly and golden on top.

Top Tip

After making this dish countless times, I've learned some little tricks that really up your game and keep the roll-ups perfectly creamy and flavorful.

Rest the chicken: Let your blackened chicken rest before dicing it so the juices redistribute and don’t dry out the filling.
Don’t overcook noodles: Slightly undercooked noodles hold their shape and roll better, avoiding mushiness after baking.
Drain spinach well: Excess moisture from spinach can make the filling watery—using a clean kitchen towel to squeeze out water is a game changer.
Use fresh garlic: It makes a huge difference in your Alfredo sauce’s flavor, so don’t skip it or substitute with pre-minced in a jar.

How to Serve Blackened Chicken Alfredo Lasagna Roll-Ups Recipe

Blackened Chicken Alfredo - Serving Suggestion

Garnishes

I love topping these roll-ups with a sprinkle of fresh parsley for color and a little cracked black pepper to add some visual texture. Sometimes, a light drizzle of extra Alfredo sauce on the plate makes each bite even more indulgent.

Side Dishes

Garlic bread or Texas toast is a must-have on the side—they soak up that extra sauce so well! A crisp Caesar salad or roasted asparagus also balances the richness and adds a fresh crunch that I love.

Creative Ways to Present

For special occasions, I’ve served these roll-ups individually plated with a small ramekin of extra Cajun-spiced Alfredo sauce for dipping. It adds a fancy touch and lets everyone personalize their spice level.

Make Ahead and Storage

Storing Leftovers

I store leftover roll-ups covered tightly with foil or plastic wrap in the fridge for up to three days. Reheat gently in the oven to keep the cheese melty rather than soggy.

Freezing

This recipe freezes beautifully! I assemble the roll-ups and freeze them before baking—just wrap well in foil and plastic wrap. When ready, thaw overnight in the fridge and bake as usual, adding a few extra minutes if needed.

Reheating

Reheating in the oven at 350°F covered with foil keeps the roll-ups moist and gooey. Avoid microwaving if you can—it tends to dry out the sauce and make the noodles rubbery.

Frequently Asked Questions:

Can I use pre-cooked chicken for this recipe?

Yes! Pre-cooked chicken can save you time. Just make sure it’s well seasoned or toss it briefly in some Cajun seasoning and olive oil to keep that smoky flavor before adding to the filling.

Can I make these roll-ups gluten-free?

Absolutely! Use gluten-free lasagna noodles and double-check that your Cajun seasoning and other ingredients don’t contain any gluten. The rest of the recipe stays the same and tastes just as delicious.

How spicy is the Blackened Chicken Alfredo Lasagna Roll-Ups Recipe?

The spice level is moderate and can easily be adjusted by varying the amount of Cajun seasoning and cayenne pepper. If you prefer mild, reduce the cayenne and opt for mild paprika instead of smoked for less intensity.

Can I prepare this recipe ahead of time for a party?

Yes! You can assemble the roll-ups a day ahead, cover tightly, and refrigerate. When ready, just bake them as directed. This is a great way to save time and keep stress low before your guests arrive.

Final Thoughts

This Blackened Chicken Alfredo Lasagna Roll-Ups Recipe holds a special place for me because it’s the perfect blend of comfort and spice—rich enough for a cozy night in, yet exciting enough to impress family or friends. Trust me, once you make these, you’ll keep coming back to this recipe as your secret weapon for delicious, fuss-free dinners that everyone raves about. I can’t wait for you to try it and make it your own!